abstract：BACKGROUND:The effectiveness of a therapeutic strategy that switches chemotherapy, based on Ki-67 tumour expression after initial therapy, relative to that of standard chemotherapy, has not been evaluated. METHODS:Patients were randomly assigned to the control arm or the Ki-67 response-guided arm (Ki-67 arm). Primary ...

journal_title：British journal of cancer

authors： Mukai H,Yamaguchi T,Takahashi M,Hozumi Y,Fujisawa T,Ohsumi S,Akabane H,Nishimura R,Takashima T,Park Y,Sagara Y,Toyama T,Imoto S,Mizuno T,Yamashita S,Fujii S,Uemura Y

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Glucocorticoids form a critical component of chemotherapy regimens and resistance to glucocorticoid therapy is predictive of poor outcome. We have previously shown that glucocorticoid resistance is associated with upregulation of t...

journal_title：British journal of cancer

authors： Toscan CE,Jing D,Mayoh C,Lock RB

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and recurrence. However, the mechanism of CSC formation, maintenance and expansion in colorectal cancer (CRC) remains poorly characterised. METHODS:The role of COP9 signalosome subunit 6 (CSN6) in regulating cancer stemness was evalu...

journal_title：British journal of cancer

authors： Qin B,Zou S,Li K,Wang H,Wei W,Zhang B,Xiao L,Choi HH,Tang Q,Huang D,Liu Q,Pan Q,Meng M,Fang L,Lee MH

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each intervention. We aimed to identify all studies evaluating the validity of PFS as a surrogate for OS in oncology, and to describ...

journal_title：British journal of cancer

authors： Belin L,Tan A,De Rycke Y,Dechartres A

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS. METHODS:A well characterised DCIS cohor...

journal_title：British journal of cancer

authors： Toss MS,Abidi A,Lesche D,Joseph C,Mahale S,Saunders H,Kader T,Miligy IM,Green AR,Gorringe KL,Rakha EA

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Stromal-tumour interactions facilitate pancreatic cancer (PC) progression. The hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the interaction between cancer cells and stromal pancreatic stellate cells (PSCs). This study assessed the effect of HGF/c-MET inhibition plus gemcitab...

journal_title：British journal of cancer

authors： Xu Z,Pang TCY,Liu AC,Pothula SP,Mekapogu AR,Perera CJ,Murakami T,Goldstein D,Pirola RC,Wilson JS,Apte MV

更新日期：2020-05-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Gkotzamanidou M,Sfikakis PP,Kyrtopoulos SA,Bamia C,Dimopoulos MA,Souliotis VL

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:There is growing evidence that spleen tyrosine kinase (SYK) is critical for acute myeloid leukaemia (AML) transformation and maintenance of the leukemic clone in AML patients. It has also been found to be over-expressed in AML patients, with activating mutations in foetal liver tyrosine kinase 3 (FLT3), part...

journal_title：British journal of cancer

authors： Yang J,Meng C,Weisberg E,Case A,Lamberto I,Magin RS,Adamia S,Wang J,Gray N,Liu S,Stone R,Sattler M,Buhrlage S,Griffin JD

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in...

journal_title：British journal of cancer

authors： Surakhy M,Wallace M,Bond E,Grochola LF,Perez H,Di Giovannantonio M,Zhang P,Malkin D,Carter H,Parise IZS,Zambetti G,Komechen H,Paraizo MM,Pagadala MS,Pinto EM,Lalli E,Figueiredo BC,Bond GL

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Faecal immunochemical tests (FITs) have replaced guaiac-based faecal occult blood test (gFOBTs) in several colorectal cancer (CRC) screening programmes. We aimed to evaluate the benefits of this transition based on the Wallonia-Brussels-organised CRC screening programme. METHODS:A total of 1,569,868 individ...

journal_title：British journal of cancer

authors： Guo F,De Brabander I,Francart J,Candeur M,Polus M,Van Eycken L,Brenner H

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Dyskeratosis congenita 1 (DKC1) is dysregulated in several cancers. However, the expression and function of DKC1 in colorectal cancer (CRC) is rarely reported. METHODS:Tissue microarrays (TAMs) including 411 cases of CRC tissues and corresponding paracancerous tissues were used to examine the DKC1 expressio...

journal_title：British journal of cancer

authors： Hou P,Shi P,Jiang T,Yin H,Chu S,Shi M,Bai J,Song J

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Low-dose UCN-01 mediates G1 arrest in normal proliferating cell lines with an intact G1 to S transition but not tumour cells with a deregulated G1 to S checkpoint. Here we hypothesised that UCN-01 is effective in mediating a selective, reversible G1 arrest of normal proliferating cells, resulting in decrease...

journal_title：British journal of cancer

authors： Mull BB,Livingston JA,Patel N,Bui T,Hunt KK,Keyomarsi K

更新日期：2020-03-01 00:00:00

abstract：:Preclinical models that can accurately predict outcomes in the clinic are much sought after in the field of cancer drug discovery and development. Existing models such as organoids and patient-derived xenografts have many advantages, but they suffer from the drawback of not contextually preserving human tumour archite...

journal_title：British journal of cancer

authors： Powley IR,Patel M,Miles G,Pringle H,Howells L,Thomas A,Kettleborough C,Bryans J,Hammonds T,MacFarlane M,Pritchard C

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Immune checkpoint blockade (ICB) therapy improved the prognosis of cancer patients, but general administration of ICBs occasionally induces side effects that include immune-related adverse events and tumour hyper-progression. Here, we established a protein-based system, by which endogenous expression of IC m...

journal_title：British journal of cancer

authors： Teratake Y,Takashina T,Iijima K,Sakuma T,Yamamoto T,Ishizaka Y

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Circulating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. METHODS:Here we compared two microfluidi...

journal_title：British journal of cancer

authors： Aya-Bonilla CA,Morici M,Hong X,McEvoy AC,Sullivan RJ,Freeman J,Calapre L,Khattak MA,Meniawy T,Millward M,Ziman M,Gray ES

更新日期：2020-03-01 00:00:00

abstract：:Pancreatic cancers occurring in carriers of a pathogenic germline alteration in BRCA1/2 (gBRCA1/2) are assumed to demonstrate homologous recombination repair deficiency (HRD), associated with sensitivity to platinum-based chemotherapy and synthetic lethality with PARP inhibitors (PARPi). However, primary and secondary...

journal_title：British journal of cancer

authors： Lowery MA

更新日期：2020-02-01 00:00:00

abstract：:The traditional cancer drug development pathway is increasingly being superseded by trials that address multiple clinical questions. These are collectively termed Complex Innovative Design (CID) trials. CID trials not only assess the safety and toxicity of novel anticancer medicines but also their efficacy in biomarke...

journal_title：British journal of cancer

authors： Blagden SP,Billingham L,Brown LC,Buckland SW,Cooper AM,Ellis S,Fisher W,Hughes H,Keatley DA,Maignen FM,Morozov A,Navaie W,Pearson S,Shaaban A,Wydenbach K,Kearns PR,Experimental Cancer Medicine Centres (ECMC) CID trials wo

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The aim of this work was to improve the knowledge of the role of histamine in breast cancer by assessing the therapeutic efficacy of histamine and histamine H4 receptor (H4R) ligands in a triple-negative breast cancer (TNBC) model developed in immunocompetent hosts. By using publicly available genomic data, ...

journal_title：British journal of cancer

authors： Nicoud MB,Sterle HA,Massari NA,Táquez Delgado MA,Formoso K,Herrero Ducloux MV,Martinel Lamas D,Cremaschi GA,Medina VA

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Tumour microenvironments can differ according to intratumoural locations. We investigated the immune status at different locations in primary tumours and its clinical significance in oesophageal squamous cell carcinoma (ESCC). METHODS:The number of CD8+ tumour-infiltrating immune cells (TIICs) and PD-1+ TII...

journal_title：British journal of cancer

authors： Hatogai K,Fujii S,Kitano S,Kojima T,Daiko H,Yoshino T,Ohtsu A,Takiguchi Y,Doi T,Ochiai A

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Stathmin mediates cell migration and invasion in vitro, and metastasis in vivo. To investigate stathmin's role on the metastatic process, we performed integrated mRNA-miRNA expression analysis to identify pathways regulated by stathmin. METHODS:MiRNA and gene arrays followed by miRNA-target-gene integration...

journal_title：British journal of cancer

authors： Po'uha ST,Le Grand M,Brandl MB,Gifford AJ,Goodall GJ,Khew-Goodall Y,Kavallaris M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The incidence of oesophageal adenocarcinoma is increasing globally. Barrett's oesophagus (BO) is a pre-malignant condition with no biomarker to risk stratify those at highest risk of dysplasia and malignant transformation. METHODS:Subcellular epithelial protein (HMGB1, p53, RUNX3) expression, alongside expr...

journal_title：British journal of cancer

authors： Porter RJ,Murray GI,Brice DP,Petty RD,McLean MH

更新日期：2020-02-01 00:00:00

abstract：:Window of opportunity trials exploit the 'window' of time after cancer diagnosis, typically prior to initiation of cancer therapy. In recent years this study design has become a more regular feature of drug development, as this 'window' provides an opportunity to carry out a thorough pharmacodynamic assessment of a th...

journal_title：British journal of cancer

authors： Aroldi F,Lord SR

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) has poor survival and treatment options. PDAC cells shift their metabolism towards glycolysis, which fuels the plasma membrane calcium pump (PMCA), thereby preventing Ca2+-dependent cell death. The ATP-generating pyruvate kinase-M2 (PKM2) is oncogenic and overexpressed...

journal_title：British journal of cancer

authors： James AD,Richardson DA,Oh IW,Sritangos P,Attard T,Barrett L,Bruce JIE

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant...

journal_title：British journal of cancer

authors： Jesinghaus M,Boxberg M,Wilhelm D,Münch S,Dapper H,Quante M,Schlag C,Lange S,Budczies J,Konukiewitz B,Mollenhauer M,Schlitter AM,Becker KF,Feith M,Friess H,Steiger K,Combs SE,Weichert W

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. METHODS:Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates...

journal_title：British journal of cancer

authors： Genus TSE,Bouvier C,Wong KF,Srirajaskanthan R,Rous BA,Talbot DC,Valle JW,Khan M,Pearce N,Elshafie M,Reed NS,Morgan E,Deas A,White C,Huws D,Ramage J

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal c...

journal_title：British journal of cancer

authors： Dashti SG,Li WY,Buchanan DD,Clendenning M,Rosty C,Winship IM,Macrae FA,Giles GG,Hardikar S,Hua X,Thibodeau SN,Figueiredo JC,Casey G,Haile RW,Gallinger S,Le Marchand L,Newcomb PA,Potter JD,Lindor NM,Hopper JL,Jenki

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Cancer survival statistics are typically reported by using measures discounting the impact of other-cause mortality, such as net survival. This is a hypothetical measure and is interpreted as excluding the possibility of cancer patients dying from other causes. Crude probability of death partitions the all-c...

journal_title：British journal of cancer

authors： Wong KF,Lambert PC,Mozumder SI,Broggio J,Rutherford MJ

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. METHODS:We established gastric cancer patient-derived cells (PDCs) to examine the contribution o...

journal_title：British journal of cancer

authors： Mashima T,Iwasaki R,Kawata N,Kawakami R,Kumagai K,Migita T,Sano T,Yamaguchi K,Seimiya H

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:After radical prostatectomy (RP) for prostate cancer (PC), p53 alterations predict biochemical relapse (BCR), however, recent evidence suggests that metastatic relapse (MR) not BCR is a surrogate for PC specific mortality (PCSM). This updated analysis of a previously published study investigated the associat...

journal_title：British journal of cancer

authors： Quinn DI,Stricker PD,Kench JG,Grogan J,Haynes AM,Henshall SM,Grygiel JJ,Delprado W,Turner JJ,Horvath LG,Mahon KL

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Antihypertensives may inhibit pancreatic carcinogenesis. We examined the association between use of these drugs and pancreatic cancer in patients with chronic pancreatitis. METHODS:We conducted a nationwide population-based cohort study of all chronic pancreatitis patients diagnosed in Denmark during 1996-2...

journal_title：British journal of cancer

authors： Kirkegård J,Mortensen FV,Cronin-Fenton D

更新日期：2019-10-01 00:00:00

abstract：:Chemotherapy during a viable pregnancy may be associated with adverse perinatal outcomes. We conducted a prospective cohort study to examine the perinatal outcomes of babies born following in utero exposure to chemotherapy in Australia and New Zealand. Over 18 months we identified 24 births, of >400 g and/or >20-weeks...

journal_title：British journal of cancer

authors： Safi N,Anazodo A,Dickinson JE,Lui K,Wang AY,Li Z,Sullivan EA

更新日期：2019-10-01 00:00:00

abstract：:Photodynamic diagnosis and therapy have emerged as a promising tool in oncology. Using the visible fluorescence from photosensitisers excited by light, clinicians can both identify and treat tumour cells in situ. Protoporphyrin IX, produced in the penultimate step of the haem synthesis pathway, is a naturally occurrin...

journal_title：British journal of cancer

authors： McNicholas K,MacGregor MN,Gleadle JM

更新日期：2019-10-01 00:00:00

abstract：:This article was originally published under a standard license to Publish, but has now been made available under a CC BY license. The PDF and HTML versions of the paper have been modified accordingly.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Evans TRJ,Kudo M,Finn RS,Han KH,Cheng AL,Ikeda M,Kraljevic S,Ren M,Dutcus CE,Piscaglia F,Sung MW

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Determining the rate of breast cancer (BC) growth in vivo, which can predict prognosis, has remained elusive despite its relevance for treatment, screening recommendations and medicolegal practice. We developed a model that predicts the rate of in vivo tumour growth using a unique study cohort of BC patients...

journal_title：British journal of cancer

authors： Bhattarai S,Klimov S,Aleskandarany MA,Burrell H,Wormall A,Green AR,Rida P,Ellis IO,Osan RM,Rakha EA,Aneja R

更新日期：2019-09-01 00:00:00

abstract：:Ductal carcinoma in situ (DCIS) now represents 20-25% of all 'breast cancers' consequent upon detection by population-based breast cancer screening programmes. Currently, all DCIS lesions are treated, and treatment comprises either mastectomy or breast-conserving surgery supplemented with radiotherapy. However, most D...

journal_title：British journal of cancer

authors： van Seijen M,Lips EH,Thompson AM,Nik-Zainal S,Futreal A,Hwang ES,Verschuur E,Lane J,Jonkers J,Rea DW,Wesseling J,PRECISION team.

更新日期：2019-08-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) were originally presumed to represent a homogeneous population uniformly driving tumorigenesis, united by their morphology and peritumoural location. Our understanding of CAFs has since been shaped by sophisticated in vitro and in vivo experiments, pathological association and, mor...

journal_title：British journal of cancer

authors： Gieniec KA,Butler LM,Worthley DL,Woods SL

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:A phase Ib study of binimetinib and capecitabine for gemcitabine-pretreated biliary tract cancer (BTC) patients was conducted. METHODS:Binimetinib and capecitabine were dosed twice daily on days 1-14, in 3-week cycles. In the dose-escalation (DE) part, three dose levels (DL) were tested (DL1: binimetinib/ca...

journal_title：British journal of cancer

authors： Kim JW,Lee KH,Kim JW,Suh KJ,Nam AR,Bang JH,Bang YJ,Oh DY

更新日期：2019-08-01 00:00:00

abstract：:A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Weisberg E,Manley P,Mestan J,Cowan-Jacob S,Ray A,Griffin JD

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Limited evidence exists regarding associations between obesity and kidney cancer among Asians. We examined the associations between obesity measures and risk of kidney cancer. METHODS:We included 23,313,046 adults who underwent health examinations provided by the Korean National Health Insurance Service 200...

journal_title：British journal of cancer

authors： Nam GE,Cho KH,Han K,Kim CM,Han B,Cho SJ,Jung SJ,Kwon Y,Kim YH,Kim DH,Kim SM,Choi YS,Roh YK,Park YG

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Lymphovascular invasion (LVI) is associated with the development of metastasis in invasive breast cancer (BC). However, the complex molecular mechanisms of LVI, which overlap with other oncogenic pathways, remain unclear. This study, using available large transcriptomic datasets, aims to identify genes assoc...

journal_title：British journal of cancer

authors： Kurozumi S,Joseph C,Sonbul S,Alsaeed S,Kariri Y,Aljohani A,Raafat S,Alsaleem M,Ogden A,Johnston SJ,Aleskandarany MA,Fujii T,Shirabe K,Caldas C,Ashankyty I,Dalton L,Ellis IO,Desmedt C,Green AR,Mongan NP,Rakha EA

更新日期：2019-06-01 00:00:00